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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S1
All Species:
33.94
Human Site:
Y235
Identified Species:
82.96
UniProt:
P05198
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05198
NP_004085.1
315
36112
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
P68101
315
36090
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505360
315
36118
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Chicken
Gallus gallus
Q5ZLX2
315
36160
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Frog
Xenopus laevis
Q7ZTK4
315
36026
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Zebra Danio
Brachydanio rerio
NP_571875
315
36121
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P41374
341
38627
Y233
N
L
I
A
P
P
L
Y
V
M
T
T
S
T
T
Honey Bee
Apis mellifera
XP_001122232
303
33959
G235
N
K
I
T
S
L
G
G
V
F
N
V
Q
M
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_779939
313
35603
Y234
N
L
I
A
P
P
Q
Y
V
V
T
T
Q
T
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P20459
304
34699
Y228
K
L
V
A
A
P
L
Y
V
L
T
T
Q
A
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
99
N.A.
97.7
97.1
92.6
94.2
N.A.
58
44.7
N.A.
69.5
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
99.6
N.A.
98.7
98.7
98.7
97.1
N.A.
71.8
60
N.A.
81.2
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
100
100
100
100
N.A.
80
20
N.A.
80
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
100
100
100
100
N.A.
86.6
20
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
52.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
73
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
90
10
0
0
0
0
0
0
0
0
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
90
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
90
0
0
0
10
20
0
0
10
0
0
0
0
80
% L
% Met:
0
0
0
0
0
0
0
0
0
70
0
0
0
10
0
% M
% Asn:
90
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
80
90
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
30
0
0
% Q
% Arg:
0
0
0
0
0
0
60
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% S
% Thr:
0
0
0
10
0
0
0
0
0
0
90
90
60
80
10
% T
% Val:
0
0
10
0
0
0
0
0
100
10
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
90
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _